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Volume 4
Main Index

Issue 1


Analgetics Based on the Pyrrolidine Ring
J. F. Cavalla, J. Davoll, M. J. Dean, C. S. Franklin, D. M. Temple, J. Wax, and C. V. Winder
pp 1 - 19; DOI:
10.1021/jm50017a001
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Norcotinine (Desmethylcotinine) as a Urinary Metabolite of Nornicotine
Einosuke Wade, Edward R. Bowman, Lennox B. Turnbull, and Herbert McKennis
pp 21 - 30; DOI:
10.1021/jm50017a002
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The Effects of Some Derivatives of Gamma-Aminobutyric Acid on the Slowly Adapting Stretch Receptor of Astacus Fluviatilis
Muriel E. Farquharson and J. A. R. Maclean
pp 31 - 40; DOI:
10.1021/jm50017a003
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Synthesisand Hypoglycemic Activity of Trifluoromethylated Sulphonylureas
Y. G. Perron, M. H. Pindell, L. B. Crast, and L. C. Cheney
pp 41 - 49; DOI:
10.1021/jm50017a004
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Derivatives of Hydroxylamine : Central Nervous System Stimulants
Randolph T. Major and Karl W. Ohly
pp 51 - 65; DOI:
10.1021/jm50017a005
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Domethylation Studies--I., The Effect of Chemical Structure and Lipis Solubility
Robert E. McMahon
pp 67 - 78; DOI:
10.1021/jm50017a006
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!-Substituted 2,5-Bischloromethylpyrrolidines. A New Class of Adrenolytic Agents
Edger Schipper, Werner R. Boehme, Mary Lee Graeme, Estelle Siegmund, and Edwin Chinery
pp 79 - 95; DOI:
10.1021/jm50017a007
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The Metabolism of Arylthioureas--I. The Metabolism of 1,3-Diphenyl1-2-Thiourea (Thicarbanilide) and its Derivatives
R. L. Smith and R. T. Williams
pp 97 - 107; DOI:
10.1021/jm50017a008
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The Metabolism of Arylthioureas--II. The Metabolism of 14C- and 35S-Labelled 1-Phenyl-2-Thiourea and its Derivatives
R. R. Scheline, R. L. Smith, and R. T. Williams
pp 109 - 135; DOI:
10.1021/jm50017a009
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The Metabolism of Arylthioureas--III. (a) The Toxicity of Hydrogen Sulphide in Relation to that of Phenylthiourea. (b) The Protection of Rats against the Toxic Effects of Phenylthiourea, with 1-Methyl-1-Phenylthiourea
R. L. Smith and R. T. Williams
pp 137 - 146; DOI:
10.1021/jm50017a010
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The Metabolism of Arylthioureas--IV. p-Chorophenyl- and p-Tolyl-thiourea
R. L. Smith and R. T. Williams
pp 147 - 162; DOI:
10.1021/jm50017a011
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The Metabolism of Arylthioureas--V. The Matabolism of 1-(P-Butoxyphenyl)-3-(P-Dimethylaminophenyl)-2-Thiourea(Ciba-1906, Thiambutosine)
R. L. Smith and R. T. Williams
pp 163 - 176; DOI:
10.1021/jm50017a012
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Antibacterial Agents. Some New Guanyhydrazone Derivatives
G. Cavallini, E. Massarani, D. Nardi, L. Mauri, and P. Mantegazza
pp 177 - 182; DOI:
10.1021/jm50017a013
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Structure--Activity Relationships in a Series of Antiarrhythmic and Local Anaesthetic Bicyclic Glycinamides
Werner R. Boehme, Mary Lee Graeme, William G. Scharpf, Estelle Siegmund, Edgar Schipper, and Martin Tobkes
pp 183 - 205; DOI:
10.1021/jm50017a014
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Synthesis of Penicillins Using Dicyclohexylcarbodiimide as a Condensing Agent
Donald C. Hobbs and Arthur R. English
pp 207 - 210; DOI:
10.1021/jm50017a015
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Demethylation Studies--II. The Competitive Inhibition of Microsomal N-Demethylating Enzyme by a Primary Amine, 2,4-Dichloro-6-phenylphenoxyethylamine (DPEA)
Robert E. McMahon and Jack Mills
pp 211 - 213; DOI:
10.1021/jm50017a016
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Issue 2


The Effect of Alkyl Substitution in Drugs--IV. Pharmacological Properties of Tropinyl 2-Methyl-benzhydryl Ether Hydrobromide (BS 6825)
A. B. H. Funcke, A. F. Harms, M. C. De Jonge, and W. Th. Nauta
pp 215 - 224; DOI:
10.1021/jm50018a001
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Dialkylaminoalkyl Diphenylphosphine Oxides
Alfred Burger and William H. Shelver
pp 225 - 230; DOI:
10.1021/jm50018a002
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Synthese und Pharmakologie einiger 3,5-di-und trisubstituierter Hydantoine
K. Schlögl, F. Wessely, O. Kraupp, and H. Stormann
pp 231 - 258; DOI:
10.1021/jm50018a003
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A Study of the Inhibitory Effect of Various Hydrazides on Monoamine Oxidase in vitro and in vivo
Jacob Szmuszkovicz and Margaret E. Greig
pp 259 - 296; DOI:
10.1021/jm50018a004
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Ethynyl and Styryl Compounds of the Prodine Type
N. J. Harper and S. E. Fullerton
pp 297 - 316; DOI:
10.1021/jm50018a005
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N-Alkoxy-N-alkyl(aryloxy)acetamides and their Hypnotic Activity
Randolph T. Major and Karl W. Ohly
pp 317 - 326; DOI:
10.1021/jm50018a006
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Synthesis of 2,3,6,11-Tetramethoxy-5(12H)-naphthacenone as an Analogue of Tetracycline
John B. Data and Raymond D. Bennett
pp 327 - 333; DOI:
10.1021/jm50018a007
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The Effect of Alkyl-Substitution in Drugs--V. Synthesis and Chemical Properties of Some Dibenzo [a,d]1,4-cycloheptadienyl Ethers
C. van Der Stelt, A. F. Harms, and W. Th. Nauta
pp 335 - 349; DOI:
10.1021/jm50018a008
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1,2,4-Oxadiazoles--IV. Synthesis and Pharmacological Properties of a Series of Substituted Aminoalkyl-1,2,4-oxadiazoles
G. Palazzo, M. Tavella, G. Strani, and B. Silvestrini
pp 351 - 367; DOI:
10.1021/jm50018a009
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The Syntheses of 7-Sulphamylpyrido[2,3-e]-1,2,4-Thiadiazine-1,1-Dioxide, 5,Sulphamylpyrido[4,3-e]-1,2,4-Thiadiazine-1,1-Dioxide and Certain of Their Derivatives
Edward J. Cragoe, James A. Nicholson, and James M. Sprague
pp 369 - 383; DOI:
10.1021/jm50018a010
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Analgesics--I. 4-Acyloxy-3,4-Diphenyl-1-Methylpiperidines
Arthur A. Patchett and Fred F. Giarrusso
pp 385 - 392; DOI:
10.1021/jm50018a011
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Analgesics--II. Compounds Related to 1-Acyloxy-1-benzyl-2-dimethylaminomethyl-1,2,3,4-terra-hydronaphthalene
Arthur A. Patchett and Fred F. Giarrusso
pp 393 - 402; DOI:
10.1021/jm50018a012
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Analgesics--III. Homologous Methadones
Arthur A. Patchett and Fred F. Giarrusso
pp 403 - 409; DOI:
10.1021/jm50018a013
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A New Group of Tranquillizers: Derivatives of 2,3:6,7-Dibenzosuberane and 2,3:6,7-Dibenzo-4-suberene
M. Protiva, V. Hněvsová-Seidlová, Z. J. Vejdělek, I. Jirkovský, Z. Votava, and J. Metyšová
pp 411 - 415; DOI:
10.1021/jm50018a014
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Book Review
Charles S. Davis
pp 417 - 417; DOI:
10.1021/jm50018a015
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Issue 3


Weakly Basic Analogues of Potent Analgesics
A. H. Beckett and J. V. Greenhill
pp 423 - 436; DOI:
10.1021/jm50019a001
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Dimethylation Studies--III. The in vitro Demethylation of Dialkylmethylamines
Robert E. McMahon and Nelson R. Easton
pp 437 - 445; DOI:
10.1021/jm50019a002
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A New Class of Hypocholesteremic Agents: Arylalkyl Hydrogen Succinates and Glutarates
G. Palazzo, M. Tavella, and G. Strani
pp 447 - 456; DOI:
10.1021/jm50019a003
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Symposium on the Chemistry of Toxic Substances I. Introduction to the Symposium
Vernon H. Cheldelin
pp 457 - 458; DOI:
10.1021/jm50019a004
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II. Some Chemical and Physical Properties of Paralytic Shellfish Poisons Related to Toxicity
Edward J. Schantz
pp 459 - 468; DOI:
10.1021/jm50019a005
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III. Some New Approaches to Studying the Mode of Action of Central Nervous System Poisons
L. G. Abood
pp 469 - 481; DOI:
10.1021/jm50019a006
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IV. Toxic Constituents of the Castor Bean
Alsoph H. Corwin
pp 483 - 496; DOI:
10.1021/jm50019a007
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V. Bacterial Endotoxins
Otto Westphal, Otto Lüderitz, and Anne Marie Staub
pp 497 - 504; DOI:
10.1021/jm50019a008
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VI. The Peripheral Actions of the Hemicholinium Compounds
J. P. Long
pp 505 - 510; DOI:
10.1021/jm50019a009
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VII. A Toxic (Histamine-Releasing)Principle from Tentacles of Cyanea capillata (the Stinging Jelly-fish)
Börje Uvnäs
pp 511 - 515; DOI:
10.1021/jm50019a010
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Alicyclic Alkylamines and Alkanolamines
Alfred Burger, Robert T. Standridge, Nils E. Stjernström, and Paolo Marchini
pp 517 - 534; DOI:
10.1021/jm50019a011
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Chemistry and Pharmacology of 4-Alkoxy-piperidines Related to Reversed Esters of Pethidine
A. F. Casy, A. H. Beckett, G. H. Hall, and D. K. Vallance
pp 535 - 551; DOI:
10.1021/jm50019a012
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Studies on a New Antianaemic Preparation--Diaquo-bis (N-ethylidene-threoninato) Iron (II) (FT-410) (I)
K. Higaki, S. Imado, and Y. Kowa
pp 553 - 570; DOI:
10.1021/jm50019a013
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1-Methyl-2-phenylcyclopropylamine
Alfred Burger, Charles S. Davis, Harry Green, David H. Tedeschi, and Charles L. Zirkle
pp 571 - 574; DOI:
10.1021/jm50019a014
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The Effect of Alkyl Substitution in Drugs--VI ortho-Ethyl Substituted N,N-Diethylaminoacetanilides
A. F. Harms, H. M. Tersteege, and W. Th. Nauta
pp 575 - 577; DOI:
10.1021/jm50019a015
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Book Reviews

pp 579 - 586; DOI:
10.1021/jm50019a016
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